If you want to open a photo from Excire Foto by right-clicking on it, but the call does not work, please proceed as follows:
In Excire Foto: right click on the image on "Show in file browser" and then from Windows Explorer right click -> "Open with" to open the image in the desired application.
After that, it usually works from Excire Foto as well via "Open with...".
If you cannot open the image in the desired application, there is either a problem with the installation of that application or the image file is not supported by the program.

Lightroom generally does not support opening individual files. The Lightroom database is always opened.